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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Circadian Clock Associated 1 ： ウィキペディア英語版 Circadian Clock Associated 1 Circadian Clock Associated 1 (CCA1) is a gene that is central to the circadian oscillator of angiosperms. It was first identified in ''Arabidopsis thaliana'' in 1993. CCA1 interacts with LHY and TOC1 to form the core of the oscillator system. CCA1 expression peaks at dawn. Loss of CCA1 function leads to a shortened period in the expression of many other genes.〔Green, RM. "Loss of the circadian clock-associated protein 1 in Arabidopsis results in altered clock-regulated gene expression." Proc Natl Acad Sci U S A. Vol. 96. (1999)〕 ==Discovery== CCA1 was first identified in ''Arabidopsis thaliana'' by Elaine Tobin’s lab in UCLA in 1993.〔Kenigsbuch, David, and Elaine M. Tobin. " A Region of the Arabidopsis fhcb7 *3 Promoter That Binds to CA-1 Activity 1s Essential for High Expression and Phytochrome Regulation. Plant Physiol" Plant Physiol. Vol. 108. (1995): 1023-1027.〕 Tobin’s lab was studying promoter fragments that contribute to light regulation of light-harvesting Chlorophyll A/B Binding Protein (LHCB), and noticed DNA-binding activity that had affinity for a specific light-responsive fragment of the LHCB promoter. This DNA-binding activity was designated as CA-1 because the binding is mostly to cytosine and adenine-rich sequences.〔Salomé, Patrice, and Robertson McClung. "The Arabidopsis thaliana Clock" JOURNAL OF BIOLOGICAL RHYTHMS Vol. Vol. 19 No. 5. (2004): 425-435.〕 They found that this binding activity is necessary for phytochrome response. They later found the gene responsible for this activity by screening the ''Arabidopsis'' expression library. CCA1 referred to the CA-1 clone, and now designated the gene responsible for this DNA binding activity.〔 The evolution of circadian clocks in land plants is not understood, because circadian rhythms have received little attention in plants other than angiosperms.〔Okada, Ryo, and Robertson McClung. "Functional characterization of CCA1/LHY homolog genes, PpCCA1a and PpCCA1b, in the moss Physcomitrella patens" The Plant Journal Vol. 60. (2009): 551–563.〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Circadian Clock Associated 1」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.